Sustainable Mechanosynthesis of Biologically Active Molecules

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities all kinds. This Review is focused on examples reported so far known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, prepared mechanosynthesis. Three families molecules are discussed: heterocyclic compounds, metal complexes peptides. Advantages mechanochemistry approach highlighted especially from a green chemistry efficacy point view.